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|Criticism=One of the main criticisms Kant received was targeted towards the premises he used for the deduction of the Principle. To recall, the premises were: Absolute certainty exists, and a world with no strict causal relationships is unknowable. For the first premise, fallibilists dismantled the view that absolute certainty in science exists after the acceptance of Einstein’s theory of general relativity which replaced Newtonian mechanics. Fallibilism was further exemplified with the acceptance of quantum mechanics along with general relativity by the scientific community despite the irreconcilable contradictions that arise when examining extreme conditions, which illustrated that the scientific community itself does not operate by assuming absolute certainty.
Another criticism of Kant was again, targeted at one of the premises of the Principle. Kant held a strict determinist perspective when devising his Principle, and in light of more recent advances in quantum theory, we know that a certain cause does not necessarily yield a certain outcome. Using the example of a radioactive molecule and its half life, we know that by the definition of “half life” being “the time period where the probability of a radioactive atom decays is 50%”, and as such the atom may or may not decay at a specific time (i.e. at the exact half life value) but rather any time within that timeframe<ref>Anon., n.d. Radioactive Half Life. [Online] Available at: http://hyperphysics.phy-astr.gsu.edu/hbase/Nuclear/halfli2.html [Accessed 27 11 2016].</ref>.
A third criticism was presented by A.J. Ayer (1910-1989),[[CiteRef::Ayer (1952)]] where he criticised Kant for conflating the psychological and epistemological criteria of evaluating analytic/synthetic statements. In the example Kant gives of “7+5=12” being a synthetic statement, and “all bodies are extended” being an analytic statement, Kant employs 2 different criterion and equates the two without clarification. In the first statement, Kant deems it synthetic as the definitions of “7” and “5” are not contained in “12”. On the other hand, Kant evaluates “all bodies are extended” as analytic simply because it would be contradictory if otherwise. However, a person with knowledge of the symbol “+” would understand that when put together, “7+5” does indeed share the same concept as “12”, and this statement would be analytic if evaluated as the second statement has been.