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Both Newton’s physics and philosophy were heavily influenced by Descartes’ ideas though they were also a challenge to what had, by then, become the new Cartesian orthodoxy. Descartes' '''mechanical natural philosophy''' was derived from ancient Greek atomism. He was the most prominent member of a community of '''corpuscularist''' thinkers, who maintained that visible objects were made of unobservably tiny particles, whose relations and arrangement were responsible for the properties of visible bodies. Particles influenced one another only by direct physical contact, which was the cause of all motion, and ultimately all change.[[CiteRef::Disalle (2004)]] Aristotle had explained the properties of visible bodies in terms of their form, rather than in terms of the arrangement of their constituent parts. He maintained that heavy objects, composed of the element earth, tended towards their natural place; the center of the universe. The concept of a sphere of earth at rest in the center of the universe was central to Aristotle's entire cosmology. Motion in the terrestrial and celestial realms were seen as fundamentally different.[[CiteRef::Bodnar (2016)]] Descartes' theories explained gravity as due to a swirling vortex of particles around the Earth, which pushed things towards its center. Celestial motions were not different in kind. In accord with Copernican heliocentrism, Descartes posited that a larger vortex surrounded the sun, with the smaller planetary vorticies caught in a larger solar vortex.[[CiteRef::Garber (1992)]][[CiteRef::Disalle (2004)]] In Newton's time, major champions of the mechanical natural philosophy included Christiaan Huygens (1629-1695) and Gottfried Wilhelm Leibniz (1646-1716), who was to become a major rival of Newton's. By the time Newton published his magnum opus, ''Philosophiae Naturalis Principia Mathematica'' (''Mathematical Principles of Natural Philosophy'')in 1687, Descartes' views had been accepted at Cambridge. The title of Newton's work suggests he intended it to be in dialog with Descartes' ''Principia Philosophiae'' (''Principles of Philosophy'') published in 1644.[[CiteRef::Janiak (2016)]] Newton contested Cartesianism as the orthodoxy he sought to overturn.
Descartes saw the ultimate justification of knowledge claims to lie with human reason and the absence of doubt. He relied on classical methods of theorizing and conjectured hypotheses in order to construct scientific propositions.[[CiteRef::Janiak (2016)]] Such a '''rationalist''' approach to knowledge was also championed by Baruch Spinoza (1632-1677), Nicolas Malebranche (1638-1715), and by Gottfried Wilhelm Leibniz.[[CiteRef::Lennon and Dea (2014)]] But, by the early 17th century, experimental researchers like Galileo Galilei and Robert Boyle (1627-1691) had begun to elaborate and practice a very different approach to knowledge based on experimentation and extensive use of mathematics. Following the inductive methodology advocated by [[Francis Bacon]](1561-1626), they maintained that theoretical principles emerged from experimental data by a process of inductive generalization. However, there were also dissenters like Newton's contemporary Christiaan Huygens, who believed that most experimental work involved formulating hypotheses about unobservable entities, which were tested by their observable consequences. This was an early form of hypothetico-deductivism. Newton rejected Cartesian rationalism, and argued that the Cartesians did not sufficiently employ mathematics and experimentation in their work. He rejected and the method of hypotheses outright. [[CiteRef::McMullin (2001)]][[CiteRef::Janiak (2016)]] He supported inductivism, and held epistemological views similar to those of his contemporary and friend [[John Locke]](1632-1704), who maintained that all knowledge came from experience.[[CiteRef::Rogers (1982)]]
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