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<blockquote>
#) No more cause of natural things should be admitted than are both true and sufficient to explain their phenomena#) Therefore, the causes assigned to natural effects of the same kind must be, so far as possible, the same#) Those qualities of bodies that cannot be intended and remitted (i.e. qualities that cannot be increased and diminished) and that belong to all bodies on which experiments can be made should be taken as qualities of all bodies universally#) In experimental philosophy, propositions gathered from phenomena by induction should be considered either exactly or very nearly true nonwithstanding notwithstanding any contrary hypothesis, until yet other phenomena make such propositions either more exact or liable to exceptions.[[CiteRef::Newton (1999)|pp. 794-796]]</blockquote>
Out of these four rules a new, engaged method for conducting science emerged that stood in stark contrast the previous passive and theoretical Cartesian and Aristotelian-scholastic methods. Propositions are born from natural sources and placed back into the natural world to be tested empirically.[[CiteRef::Smith (2002)]] As the four rules were absorbed into the ensuing mosaic, the calculus became deeply incorporated in the experimental method, as it was used to mathematically calculate from natural laws an empirical prediction, and then evaluate how exactly the prediction matched the observed reality.
