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Popper advocated a '''hypothetico-deductive method''' for science, arguing that science is created by conjecture and criticism rather than by reference to the past. Popper believed that Hume was mistaken in seeking a means to justify knowledge. Popper, instead sought a process to reveal and correct scientific error.[[CiteRef::Popper (1963)]]
The strongest criticisms directed against Hume were based on his skepticism about theological knowledge. Due to his religious views, he was never able to obtain an academic faculty appointment. His critics called him "The Great Infidel". Hume's arguments in the ''Dialogs'' did not put a stop to the claim that natural philosophy could find evidence of intelligent design in nature, in part because Hume failed to supply an adequate alternative explanation for apparently purposeful complexity. In 1802, twenty three years after the publication of Hume's ''Dialogues'', William Paley (1743-1805), an English clergyman, expounded the design argument in his ''Natural Theology; or, Evidences of the Existence and Attributes of the Deity''. Paley argued that the purposeful sophistication of biological "contrivances", such as the eye, were clear evidence of design by an Intelligent Being. [[CiteRef::Ayala (2003)]][[CiteRef::Paley (1809)]] Among those who read and appreciated Paley's arguments were the naturalist Charles Darwin (1809-1882). In his ''Origin of Species'' (1859) Darwin argued that biological species were not separately created and are instead physically descended from pre-existing species, with all living things ultimately descended from a common ancestor. He explained Paley's contrivances by positing the process of natural selection, which he justified with extensive studies of animal breeding. By explaining the appearance of design in living systems, Darwin's theory of evolution by natural selection dealt a severe blow to the design argument among natural scientists. Scientists [[Theory Acceptance|accepted]] methodological naturalism, and theological propositions were banished from no longer considered part of the [[Scientific Mosaic|scientific mosaic]]. [[CiteRef::Ruse (1999)]][[CiteRef::Ruse (2003)]]
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